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Patricia Arquette (born April 8, 1968) is an American actress. She made her film debut in A Nightmare on Elm Street 3: Dream Warriors (1987). Her notable films include Tony Scott's True Romance (1993), Tim Burton's Ed Wood (1994), David O. Russell's Flirting with Disaster (1996), David Lynch's Lost Highway (1997), Stephen Frears's The Hi-Lo Country (1998), Martin Scorsese's Bringing Out the Dead (1999), and Andrew Davis's Holes (2003).

For her performance in Richard Linklater's Boyhood (2014), which was filmed from 2002 until 2014, she received widespread critical praise and won the Academy Award, BAFTA Award, Critics' Choice Award, Golden Globe Award, Independent Spirit Award, and SAG Award for Best Supporting Actress.

On television, she played the character Allison DuBois—based on the author and medium Allison DuBois, who claims to have psychic abilities—in the supernatural drama series Medium (2005–11). She received three Golden Globe nominations and two Emmy Award nominations, winning the Emmy Award for Outstanding Lead Actress in a Drama in 2005. Arquette also appeared in the CSI franchise as Avery Ryan, the Deputy Director of the FBI, starring in CSI: Cyber (2015–16).